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Typestatus download9/2/2023 ![]() In the modified IFCPC nomenclature, colposcopic findings are classified and described in detail, and most of them are based on typical visual appearance, especially those related to HPV16 and HPV18. Among them, the latest and most popular is the International Federation of Cervical Pathology and Colposcopy (IFCPC) nomenclature published in 2011, which was also the important basis for the 2018 American Society for Colposcopy and Cervical Pathology (ASCCP) Colposcopy Standards recommendations. As colposcopy is a subjective procedure, some colposcopic scoring and nomenclature systems have been introduced worldwide. By applying acetic acid (3–5%) and Lugol’s iodine, a colposcopist can detect abnormalities in cervical visual appearance based on changes in the epithelium and blood vessels. Currently, colposcopy-guided biopsy with histopathology is considered the gold-standard method for the diagnosis of cervical cancer and cervical intraepithelial neoplasia. Most cervical cancers and cervical intraepithelial neoplasias are attributable to persistent infection with high-risk human papillomavirus (HPV), among which types HPV16 and HPV18 account for 70% of all cases and other high-risk HPV types (HPVs 31/33/52/58, etc.) account for 30%. Globally, cervical cancer is the most common gynaecological malignancy, and in many countries, the incidence of cervical cancer is still increasing in recent years. HPV-negative lesions are prone to be large and present typical vascular patterns despite being rare. Vascular patterns in HPV52/58-positive HSIL are quite occult and tend to be missed by colposcopists. ConclusionsĪlthough being nonspecific, iodine negativity should be concerned in HPV18-positive lesions which is closely related to glandular epithelium. The sensitivity of colposcopic impression varied among HPV genotypes ( P < 0.01), being lowest in the HPV52 group. For the lesion area of HSILs, the HPV-negative group was the largest. The frequency of the occurrence of the coarse mosaic patterns was significantly different among groups ( P < 0.05), reducing in sequence were the HPV16, HPV-negative, HPV18, HPV31/33 and HPV52/58 groups. The differences in red, green, and mean greyscale values in iodine staining were significant between the HPV18 and the other groups ( P < 0.05). ![]() ![]() The differences in red, green, blue and mean greyscale values in acetowhite epithelium obtained from ImageJ were not significant between the HPV16 and HPV18 groups ( P < 0.05). ![]() Colorimetric and morphometric data of colposcopic patterns after the application of acetic acid and iodine were acquired using ImageJ software and the surrounding normal regions were used as controls. We present a reliable imaging method that provides reproducible, sensitive and unbiased assessments of cervical appearance characteristics. MethodsĪ total of 239 histopathological HSIL patients were included and divided into eight groups on the basis of HPV genotype in this prospective study. This study aimed to evaluate the differences in cervical appearance among different human papillomavirus (HPV) genotypes in patients with high-grade squamous intraepithelial lesions (HSILs). ![]()
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